Document Detail

Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis.
MedLine Citation:
PMID:  22781548     Owner:  NLM     Status:  Publisher    
BACKGROUND: We evaluated the exercise capacity of children with cystic fibrosis to determine whether ventilatory limitation associated with static hyperinflation is related with decreased exercise capacity, thus predisposing these children to arterial hypoxaemia during progressive exercise. METHODS: Thirty-seven children aged 8 - 17 years underwent spirometry, bodyplethysmography and cardiopulmonary exercise testing after arterial catheter placement. According to ratios of residual volume to total lung capacity, the subjects were stratified either as statically hyperinflated (>30%) or non-statically hyperinflated (<30%). RESULTS: Children with static hyperinflation showed lower values of maximum load per kilogram/predicted, (p = 0.001), which was aggravated by ventilatory limitation (forced expiratory volume in 1 second <80% predicted, peak oxygen consumption percent/predicted <85% and breathing reserve index >0.7). Patients with ventilatory limitation had significantly lower oxygen saturation (p = 0.039) and hypoxaemia (p = 0.027) than did patients without ventilatory limitation. CONCLUSIONS: In children with cystic fibrosis, static hyperinflation and ventilatory limitation are associated with decrease in exercise performance, oxygen saturation and oxygen pressure in arterial blood during maximum cardiopulmonary exercise testing. All children with cystic fibrosis who exhibit static hyperinflation and ventilatory limitation may require SaO₂ monitoring during progressive exercise.
Aleksandar D Sovtic; Predrag B Minic; Jovan Lj Kosutic; Gordana P Markovic-Sovtic; Gajic B Milan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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