| Static and dynamic measurements of accommodation in individuals with down syndrome. | |
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MedLine Citation:
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PMID: 20739471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To identify whether static and dynamic aspects of accommodation other than accuracy are deficient in individuals with Down syndrome (DS) and whether poor accommodation is related to sensory or motor pathway deficits. METHODS: Static aspects of accommodation (maximum accommodative response and lag) were measured with an autorefractor for both proximal and minus lens demands. Dynamic aspects of accommodation (latency, peak velocity, microfluctuations) were recorded at 30 Hz with a custom-built photorefractor as subjects viewed a movie switching between 11 m and 50, 33, 25, or 20 cm. Thirty-six subjects with DS were recruited (age 3 to 39 years), and 24 (67%) had useable responses for at least one study measurement for comparison with 140 controls (3 to 40 years) from a previously published cohort. RESULTS: DS subjects had lower maximum accommodative responses (mean = 2.52 ± 1.66 D) and higher lags (1.81 ± 1.30 D for 33 cm demand) than controls for both proximal and minus lens stimuli. DS subjects had greater microfluctuations (one-way ANCOVA, P < 0.001), and a small percentage of the total number of latency measurements (17% accommodative and 16% disaccommodative) were longer than controls. Peak velocities of accommodation and disaccommodation were not different between groups (one-way ANCOVA, P = 0.143). CONCLUSIONS: Peak velocities of accommodation and disaccommodation (primarily motor aspects) did not differ between controls and DS subjects; however, latencies (primarily sensory) and microfluctuations (combined motor and sensory) were poorer in DS subjects. These results suggest that poor accommodative accuracy in individuals with DS may be predominantly related to sensory deficits. |
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Authors:
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Heather A Anderson; Ruth E Manny; Adrian Glasser; Karla K Stuebing |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-05 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: 2011-02-07 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 310-7 Citation Subset: IM |
Affiliation:
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University of Houston College of Optometry, Houston, TX, USA. handerson@optometry.uh.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accommodation, Ocular
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physiology* Adolescent Adult Child Child, Preschool Down Syndrome / physiopathology* Female Humans Male Nystagmus, Pathologic / physiopathology Psychomotor Performance / physiology Strabismus / physiopathology Visual Acuity / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P30 EY007551-22/EY/NEI NIH HHS; P30 EY007551-23/EY/NEI NIH HHS; P30 EY007551-24/EY/NEI NIH HHS; P30 EY007551-25/EY/NEI NIH HHS; P30 EY07551/EY/NEI NIH HHS; R01EY017076-02/EY/NEI NIH HHS; T32 EY07024/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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