Document Detail

Stathmokinetic measurement of tumour cell proliferation in relation to vascular proximity.
MedLine Citation:
PMID:  6344998     Owner:  NLM     Status:  MEDLINE    
In this study the metaphase-arrest method with vincristine (VCR) was used, in a transplanted C3H mouse mammary tumour, to study cell proliferation relative to distance from a blood vessel. The metaphase-arrest method has a number of advantages over methods involving [3H]TdR labelling for such a study. The cell birth rate (kB) was shown to be inversely related to distance from a capillary in corded areas of tumour. Penetration of VCR, even into perinecrotic areas of tumour, appeared to be sufficient to achieve effective metaphase arrest.
B Jones; R S Camplejohn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue kinetics     Volume:  16     ISSN:  0008-8730     ISO Abbreviation:  Cell Tissue Kinet     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-17     Completed Date:  1983-08-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0174107     Medline TA:  Cell Tissue Kinet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / blood supply*,  physiopathology
Cell Cycle / drug effects
DNA Replication
Histological Techniques
Mammary Neoplasms, Experimental / blood supply*,  physiopathology
Mice, Inbred C3H
Mitotic Index / drug effects
Vincristine / pharmacology*
Reg. No./Substance:

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