Document Detail

State-of-the-art technology in modern computer-aided drug design.
MedLine Citation:
PMID:  23148324     Owner:  NLM     Status:  Publisher    
The quest for small drug-like compounds that selectively inhibit the function of biological targets has always been a major focus in the pharmaceutical industry and in academia as well. High-throughput screening of compound libraries requires time, cost and resources. Therefore, the use of alternative methods is necessary for facilitating lead discovery. Computational techniques that dock small molecules into macromolecular targets and predict the affinity and activity of the small molecule are widely used in drug design and discovery, and have become an integral part of the industrial and academic research. In this review, we present an overview of some state-of-the-art technologies in modern drug design that have been developed for expediting the search for novel drug candidates.
Georgios A Dalkas; Dimitrios Vlachakis; Dimosthenis Tsagkrasoulis; Anastasia Kastania; Sophia Kossida
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Briefings in bioinformatics     Volume:  -     ISSN:  1477-4054     ISO Abbreviation:  Brief. Bioinformatics     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100912837     Medline TA:  Brief Bioinform     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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