| State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future. | |
| | |
MedLine Citation:
|
PMID: 20590865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
SUMMARY: In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratory-based, imaging has become an important tool for the evaluation of complications, diagnostic confirmation and/or complementation and therapeutic follow-up in haemophilic arthropathy. Radiography remains the workforce horse in the diagnosis and follow-up of haemophilic arthropathy. The radiographical findings in arthropathy follow an expected sequence of events and are overall similar in different joints. Magnetic resonance imaging (MRI) has advantages over radiography based on its capability of visualizing soft tissue and cartilage changes in haemophilic joints. The recent development and standardization of MRI scoring systems for measuring soft tissue and cartilage abnormalities may enable the comparison of pathological joint findings in clinical trials conducted at different institutions across the world. The implementation of high-frequency transducers and colour/power Doppler capabilities has provided new insights for clinical applications of ultrasonography (US) in haemophilic arthropathy. In spite of the imaging modality's technical challenges such as operator-dependency, US has advantages over MRI. One of these advantages is its ability of differentiating synovium hypertrophy and hemosiderin deposition, which is not possible with MRI given the presence of susceptibility artefacts from extracellular hemosiderin on gradient-echo MR images. In addition to the aforementioned conventional imaging modalities, novel imaging techniques (blood oxygen level dependent, ultrasmall superparamagnetic iron-oxide contrast-enhanced, and T1 and T2 mapping MRI, ultrasound biomicroscopy, microbubble contrast-enhanced US and positron emission tomography, among others) hold promise for early assessment of haemophilic arthropathy in the future upon completion of their clinical validation. |
| | |
Authors:
|
A S Doria |
Related Documents
:
|
6942355 - New observations with routine and ct-assisted arthrography in suspected internal derang... 3608315 - Evaluation of musculoskeletal sepsis with indium-111 white blood cell imaging. 17139505 - Advanced imaging in rheumatoid arthritis. part 1: synovitis. 11245245 - Mr imaging findings in a dog with lumbar ganglion cysts. 8170305 - Capillary water determination in core plugs: a combined study based on imaging techniqu... 21045505 - Localization of pilomotor seizure demonstrated by electroencephalography /functional ma... |
Publication Detail:
|
Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: 16 Suppl 5 ISSN: 1365-2516 ISO Abbreviation: Haemophilia Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-01 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: England |
Other Details:
|
Languages: eng Pagination: 107-14 Citation Subset: IM |
Affiliation:
|
The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. andrea.doria@sickkids.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cartilage
/
pathology* Diagnostic Imaging / history* Hemarthrosis / diagnosis*, radiography, ultrasonography Hemophilia A / diagnosis*, radiography, ultrasonography History, 20th Century History, 21st Century Humans Joints / pathology* Magnetic Resonance Imaging / methods* Positron-Emission Tomography Radioisotopes / diagnostic use Signal Processing, Computer-Assisted Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mild haemophilia: a disease with many faces and many unexpected pitfalls.
Next Document: Management of arthrofibrosis in haemophilic arthropathy.