| State-of-the-art of bone marrow analysis in forensic toxicology: a review. | |
| | |
MedLine Citation:
|
PMID: 21061013 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Although blood is the reference medium in the field of forensic toxicology, alternative matrices are required in case of limited, unavailable or unusable blood samples. The present review investigated the suitability of bone marrow (BM) as an alternative matrix to characterize xenobiotic consumption and its influence on the occurrence of death. Basic data on BM physiology are reported in order to highlight the specificities of this matrix and their analytical and toxicokinetic consequences. A review of case reports, animal and human studies involving BM sample analysis focuses on the various parameters of interpretation of toxicological results: analytic limits, sampling location, pharmacokinetics, blood/BM concentration correlation, stability and postmortem redistribution. Tables summarizing the analytical conditions and quantification of 45 compounds from BM samples provide a useful tool for toxicologists. A specific section devoted to ethanol shows that, despite successful quantification, interpretation is highly dependent on postmortem interval. In conclusion, BM is an interesting alternative matrix, and further experimental data and validated assays are required to confirm its great potential relevance in forensic toxicology. |
| | |
Authors:
|
Nathalie Cartiser; Fabien Bévalot; Laurent Fanton; Yvan Gaillard; Jérôme Guitton |
Related Documents
:
|
20580173 - Atypical carcinoid of the larynx and expressions of proteins associated with molecular ... 12658753 - Clinical and biological significance of clonal macrophage detection in hemophagocytic s... 16914993 - Tattoos: a review of tattoo practices and potential treatment options for removal. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of legal medicine Volume: 125 ISSN: 1437-1596 ISO Abbreviation: Int. J. Legal Med. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9101456 Medline TA: Int J Legal Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 181-98 Citation Subset: IM |
Affiliation:
|
Université de Lyon, Université Claude Bernard Lyon 1, ISPB-Faculté de pharmacie, Laboratoire de Toxicologie, 8 avenue Rockefeller, 69373 Lyon cedex 08, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of FDG PET/CT in the staging and the follow-up of anal carcinoma.
Next Document: Stereopsis in bilaterally multifocal pseudophakic patients.