| Starvation in yeast increases non-adaptive mutation. | |
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MedLine Citation:
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PMID: 10079325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of reversion in a histidine-requiring mutant of Saccharomyces cerevisiae increases about ten-fold in stationary cells during histidine starvation. Histidine starvation enhances a similar frequency of reversion in a tryptophan-requiring mutant. Starvation, therefore, enhances mutation frequencies in a non-adaptive manner. The base analogue 6-N-hydroxylaminopurine (HAP) added prior to plating on medium with limited histidine strongly increases reversion of the histidine mutant. HAP-induced reversion increases further in stationary starving cells with the same kinetics as that which increases spontaneous reversion. Adding HAP to the stationary starving cells does not produce any effect. |
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Authors:
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A Marini; N Matmati; G Morpurgo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current genetics Volume: 35 ISSN: 0172-8083 ISO Abbreviation: Curr. Genet. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-16 Completed Date: 1999-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004904 Medline TA: Curr Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: IM |
Affiliation:
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Istituto di Anatomia comparata, University of Perugia, Via Pascoli, I-06100 Perugia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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analogs & derivatives,
pharmacology Cell Division Colony Count, Microbial Culture Media / pharmacology Histidine / pharmacology Mutation Saccharomyces cerevisiae / drug effects, genetics*, growth & development |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 5667-20-9/6-N-hydroxylaminopurine; 71-00-1/Histidine; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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