Document Detail

Starvation causes acute psychosis due to anterior thalamic infarction.
MedLine Citation:
PMID:  20531059     Owner:  NLM     Status:  MEDLINE    
A 19-year-old female presented with acute onset of bizarre behavior, confusion, auditory hallucinations, and delusions after two weeks on a 100 kcal/day diet. She had a normal neurological examination. Urinalysis showed ketones 4+. She had elevated antinuclear antibody (ANA) (320) and positive heterozygous factor V Leiden mutation. Magnetic resonance imaging brain scan showed hyperintensity in the ventroanterior nucleus of the left thalamus. Ventroanterior thalamic stroke has been associated with personality changes. This is the first case of starvation-induced thalamic psychosis in the setting of factor V Leiden mutation and elevated ANA. The patient improved with risperidone in one month.
Manoj Mittal; Saud Khan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  103     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-3     Citation Subset:  AIM; IM    
Department of Neurology, Kansas University Medical Center, Kansas City, KS, USA.
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MeSH Terms
Acute Disease
Antipsychotic Agents / therapeutic use
Factor V / genetics
Infarction / complications*,  etiology
Ketosis / etiology
Positron-Emission Tomography
Psychotic Disorders / drug therapy,  etiology*
Risperidone / therapeutic use
Starvation / complications*,  psychology
Thalamus / blood supply*
Reg. No./Substance:
0/Antipsychotic Agents; 0/factor V Leiden; 106266-06-2/Risperidone; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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