Document Detail

Starting the cell cycle: what's the point?
MedLine Citation:
PMID:  8608009     Owner:  NLM     Status:  MEDLINE    
Early work on regulation of the budding yeast cell cycle defined a critical regulatory step called 'Start', considered to represent cell cycle commitment. Recent work has defined the probable molecular basis of Start to be activation of Cln-Cdc28 protein kinase complexes. Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent.
F R Cross
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  7     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-05-28     Completed Date:  1996-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  790-7     Citation Subset:  IM    
Rockefeller University, New York, USA.
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MeSH Terms
Cell Cycle / physiology*
Time Factors
Yeasts / cytology
Grant Support

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