Document Detail


Start me up: cell signaling and the journey from oocyte to embryo in C. elegans.
MedLine Citation:
PMID:  16372336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intercellular communication plays a pivotal role in regulating and coordinating oocyte meiosis and fertilization, key triggers for embryonic development. The nematode Caenorhabaditis elegans has emerged as an important experimental paradigm for exploring these fundamental reproductive processes and their regulation. The oocytes of most animal species arrest during meiotic prophase and complete meiosis in response to intercellular signaling in the process of meiotic maturation. Oocyte meiotic maturation is defined by the transition between diakinesis and metaphase of meiosis I and is accompanied by nuclear envelope breakdown and meiotic spindle assembly. As such, the meiotic maturation process is essential for completing meiosis and a prerequisite for successful fertilization. In C. elegans, the processes of meiotic maturation, ovulation, and fertilization are temporally coupled: sperm utilize the major sperm protein as a hormone to trigger oocyte meiotic maturation, and, in turn, the maturing oocyte signals its own ovulation, leading to fertilization. The powerful genetic screens possible in C. elegans have led to the identification of several sperm cell surface proteins that are required for the interaction and fusion of gametes at fertilization. The study of these proteins provides fundamental insights into fertilization mechanisms, their role in speciation, and their potential conservation across phyla. Signaling processes sparked by fertilization are required for meiotic chromosome segregation and initiating the embryonic program. Here we review recent advances in understanding how signaling mechanisms contribute to the oocyte-to-embryo transition in C. elegans.
Authors:
Ikuko Yamamoto; Mary E Kosinski; David Greenstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  235     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-14     Completed Date:  2006-06-06     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-85     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8240, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / embryology*,  genetics
Embryo, Nonmammalian / embryology
Female
Fertilization / genetics*
Humans
Male
Meiosis*
Oocytes / growth & development*
Oogenesis / genetics
Signal Transduction
Grant Support
ID/Acronym/Agency:
GM57173/GM/NIGMS NIH HHS; GM65115/GM/NIGMS NIH HHS; R01 GM057173/GM/NIGMS NIH HHS; R01 GM065115/GM/NIGMS NIH HHS

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