Document Detail

Staring at the Cold Sun: Blue Light Regulation Is Distributed within the Genus Acinetobacter.
MedLine Citation:
PMID:  23358859     Owner:  NLM     Status:  In-Data-Review    
We previously showed that the opportunistic nosocomial pathogen Acinetobacter baumannii is able to sense and respond to light via BlsA, a BLUF (Blue-Light-sensing Using FAD)-domain photoreceptor protein. Here, we extend our previous studies showing that light regulation is not restricted to A. baumannii, but rather widespread within the genus Acinetobacter. First, we found that blue light modulates motility and biofilm formation in many species of the genus, including members of the Acinetobacter calcoaceticus-A. baumannii complex. In many of these species blue light acts as a key factor guiding the decision between motility or sessility at 24°C, whereas in A. baumannii, light inhibits both motility and biofilm formation. We also show that light regulation of motility occurred not only at 24°C but also at 37°C in non-A. baumannii species, contrasting the situation of A. baumannii which only shows photoregulation at 24°C. Second, we show that Acinetobacter baylyi (strain ADP1) BLUF-photoreceptors can functionally replace in vivo the A. baumannii 17978 BlsA protein and that the pathways leading to biofilm formation are inversely regulated at 24°C between these two microorganisms. Finally, we found the presence of predicted genes coding BLUF-containing proteins in all Acinetobacter sequenced genomes, even though the copy number is variable among them. Phylogenetic analysis suggests a common origin for all BLUF domains present in members of this genus, and could distinguish well-differentiated clusters that group together BLUF homologs from different species, a situation particularly clear for members of the ACB complex. Despite a role played by these BLUF domain-containing proteins in the photoregulation observed in the members of the genus Acinetobacter is a likely scenario given our findings in A. baumannii and A. baylyi, further research will contribute to confirm this possibility.
Adrián Golic; Mario Vaneechoutte; Alexandr Nemec; Alejandro M Viale; Luis A Actis; María Alejandra Mussi
Related Documents :
20858249 - Evolution of mantis shrimps (stomatopoda, malacostraca) in the light of new mesozoic fo...
24247609 - Covered and naked barleys from the himalaya : 1. evidence of multivariate differences b...
15792239 - Ecological adaptation and species recognition drives vocal evolution in neotropical sub...
17285319 - Gastropod grazers and nutrients, but not light, interact in determining periphytic alga...
12858259 - Spatial dynamics in model plant communities: what do we really know?
24181789 - Temporal patterns in echolocation and cave use by guam swiftlets (aerodramus bartschi) ...
8350179 - Reproducibility of tooth tapping rhythm in young and elderly dentate subjects.
909939 - Objective determinations of sensibility in the upper extremity. part ii. application of...
20858249 - Evolution of mantis shrimps (stomatopoda, malacostraca) in the light of new mesozoic fo...
Publication Detail:
Type:  Journal Article     Date:  2013-01-24
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e55059     Citation Subset:  IM    
Microbiology Division, Instituto de Biología Molecular y Celular de Rosario (IBR- CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Malleability of Mate Selection in Speed-Dating Events.
Next Document:  Further analysis of the Crouzon mouse: effects of the FGFR2(C342Y) mutation are cranial bone-depende...