| Staphylococcus sciuri exfoliative toxin C is a dimer that modulates macrophage functions. | |
| | |
MedLine Citation:
|
PMID: 21854098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Staphylococcus sciuri causes multiple infections in humans. Recently, a strain of S. sciuri (HBXX06) carrying exfoliative toxin C (ExhC) was reported to cause fatal exudative epidermal skin pathology in piglets and might be considered as a potential zoonotic agent. However, little is known about the pathogenicity of this bacterium. In this study, we examined the activity of recombinant ExhC-his (rExhC) protein using newborn mice as the model and investigated the effect of rExhC on macrophage functions. Interestingly, we found that both rExhC and S. sciuri ExhC existed as dimers and that rExhC inhibited the phagocytosis of RAW264.7 cell lines but enhanced the production of proinflammatory mediators, such as interleukin-6, interleukin-12, tumor necrosis factor α, and nitric oxide, by murine peritoneal macrophages and RAW264.7 cells. These results suggest that ExhC may play an important role in innate immune response against S. sciuri infection. |
| | |
Authors:
|
Haihua Li; Xiaying Li; Ying Lu; Xiaojia Wang; Shijun J Zheng |
Related Documents
:
|
16551748 - Conditional and specific nf-kappab blockade protects pancreatic beta cells from diabeto... 17565538 - Orchestration of the inflammatory response in ischemia-reperfusion injury. 9843778 - Early nf-kappab activation is associated with hormone-induced pancreatitis. 18241858 - Growth inhibitory effects of obovatol through induction of apoptotic cell death in pros... 7584498 - Chemokines, inflammation and the immune system. 21967868 - Involvement of the trem-1/dap12 pathway in the innate immune responses to porphyromonas... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
|
Title: Canadian journal of microbiology Volume: - ISSN: 1480-3275 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372707 Medline TA: Can J Microbiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
a State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition effects of isolated compounds from Artemisia rubripes Nakai of the classical pathway on t...
Next Document: Prognostic value of lymph-node dissection in patients undergoing radical cystectomy following previo...