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Staphylococcus lugdunensis infective endocarditis: a literature review and analysis of risk factors.
MedLine Citation:
PMID:  21195974     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Infective endocarditis caused by Staphylococcus lugdunensis is a rare disease. Since its first description in 1988, there have only been a few reports of this disease and the causative organism. These publications were primarily case reports and brief case series. We conducted a literature review to identify the nature of the disease and its risk factors.
METHODS: We retrospectively reviewed the cases reported between 1988 and 2008 by searching the relevant literature using the keywords "endocarditis" and "Staphylococcus lugdunensis" in the Medline database. All cases included met the definition of the modified Duke criteria.
RESULTS: For the period 1988-2008, 67 cases from 27 articles were reviewed. The mean age of individuals was 53.9 years. Left-sided valvular endocarditis represented 52 (82.5%) of cases and native-valve endocarditis was evident in 48 (78.7%) of cases. A large proportion (82%) of 50 S. lugdunensis strains were susceptible to penicillin. Valve replacement operations were performed in 42 (66.7%) patients and the mortality rate was 38.8%. Univariate analysis showed a higher mortality rate in patients aged more than 50 years, those treated before 1995, those treated with antibiotics alone, and those with growth not detected by echocardiography. Medical treatment alone was the independent risk factor for mortality by multivariate analysis.
CONCLUSION: S. lugdunensis endocarditis led to substantial morbidity and mortality. Detailed microbiological identification, echocardiography evaluation, and valve replacement may improve the clinical outcome of individuals with S. lugdunensis endocarditis.
Authors:
Po-Yen Liu; Yung-Feng Huang; Chia-Wan Tang; Ying-Yao Chen; Kai-Sheng Hsieh; Luo-Ping Ger; Yao-Shen Chen; Yung-Ching Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi     Volume:  43     ISSN:  1995-9133     ISO Abbreviation:  J Microbiol Immunol Infect     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956211     Medline TA:  J Microbiol Immunol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  478-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
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