Document Detail


Staphylococcus epidermidis isolated from newborn infants express pilus-like structures and are inhibited by the cathelicidin-derived antimicrobial peptide LL37.
MedLine Citation:
PMID:  19390494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coagulase-negative staphylococci and its subtype Staphylococcus epidermidis are major indigenous Gram-positive inhabitants of the human skin. Colonization occurs in direct connection with birth and terrestrial adaptation. This study focuses on factors that may influence skin colonization of the newborn infant that relates to the immune status of both the bacteria and the host. Skin is an effective barrier against bacteria, and this function is partly mediated by the presence of antimicrobial peptides including human cathelicidin peptide LL37. Gram-positive bacteria have been described to have adhesive pili on their surface that mediates specific attachment to the host. Here, we identify, by negative staining transmission electron microscopy (EM), two different types of pilus-like structures commonly expressed on S. epidermidis isolated from newborn infants. We also show that the cathelicidin antimicrobial peptide LL37, constitutively expressed in the skin barrier of the newborn, significantly inhibited growth of S. epidermidis indicating its importance for the ecological stability of the skin microbiota. Further studies are required to elucidate molecular mechanisms of host-microbe interactions, both for the maintenance of a mutually beneficial homeostatic relationship and for the protection of self when it results in overt disease.
Authors:
Annika Nelson; Kjell Hultenby; Eva Hell; Hilde M Riedel; Hjalmar Brismar; Jan-Ingmar Flock; Joachim Lundahl; Christian G Giske; Giovanna Marchini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Affiliation:
Department of Woman and Child Health, Karolinska Institutet, Stockholm 17176, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / metabolism*
Antimicrobial Cationic Peptides / metabolism*
Bacterial Proteins / genetics,  metabolism
Biofilms
Female
Fimbriae, Bacterial / metabolism*,  ultrastructure
Humans
Immunohistochemistry
Infant, Newborn
Male
Microbial Sensitivity Tests
Pregnancy
Skin / microbiology
Staphylococcal Skin Infections / metabolism
Staphylococcus epidermidis / cytology*,  metabolism*,  pathogenicity
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Bacterial Proteins; 0/cathelicidin antimicrobial peptide

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