Document Detail

The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin.
MedLine Citation:
PMID:  18005699     Owner:  NLM     Status:  MEDLINE    
Resistance to human skin innate defenses is crucial for survival and carriage of Staphylococcus aureus, a common cutaneous pathogen and nasal colonizer. Free fatty acids extracted from human skin sebum possess potent antimicrobial activity against S. aureus. The mechanisms by which S. aureus overcomes this host defense during colonization remain unknown. Here, we show that S. aureus IsdA, a surface protein produced in response to the host, decreases bacterial cellular hydrophobicity rendering them resistant to bactericidal human skin fatty acids and peptides. IsdA is required for survival of S. aureus on live human skin. Reciprocally, skin fatty acids prevent the production of virulence determinants and the induction of antibiotic resistance in S. aureus and other Gram-positive pathogens. A purified human skin fatty acid was effective in treating systemic and topical infections of S. aureus suggesting that our natural defense mechanisms can be exploited to combat drug-resistant pathogens.
Simon R Clarke; Ramlan Mohamed; Li Bian; Alexander F Routh; John F Kokai-Kun; James J Mond; Andrej Tarkowski; Simon J Foster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell host & microbe     Volume:  1     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2007-12-11     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-212     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Antigens, Bacterial / biosynthesis,  chemistry,  physiology*
Antimicrobial Cationic Peptides / pharmacology
Colony Count, Microbial
Fatty Acids / isolation & purification,  pharmacology
Hemolysin Proteins / biosynthesis
Hydrophobic and Hydrophilic Interactions
Microbial Viability
Sebum / immunology,  microbiology
Skin / chemistry,  immunology*,  microbiology
Staphylococcal Skin Infections / drug therapy,  immunology*
Staphylococcus aureus / drug effects,  immunology*,  metabolism
Virulence Factors / biosynthesis
Grant Support
G0600801//Medical Research Council
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antigens, Bacterial; 0/Antimicrobial Cationic Peptides; 0/Fatty Acids; 0/Hemolysin Proteins; 0/IsdA protein, Staphylococcus aureus; 0/Virulence Factors
Comment In:
Cell Host Microbe. 2007 May 17;1(3):161-2   [PMID:  18005694 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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