Document Detail

Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1.
MedLine Citation:
PMID:  8976639     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence of Staphylococcus aureus nasal carriage and to compare antibody responses to two superantigens, staphylococcal toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA), in rheumatoid arthritis patients and normal subjects. METHODS: 88 rheumatoid arthritis patients and 110 control subjects were cultured for nasal carriage of S aureus; 62 isolates were bacteriophage typed. Twenty five patients and 11 spouses were tested for antibodies to TSST-1, SEA, and sonicate extracts of Bacteroides fragilis and Escherichia coli; 19 patients were HLA-DR typed. RESULTS: 50% of patients and 33% of normal subjects were S aureus carriers. Bacteriophage typing of isolates suggested significant differences between strains isolated from the two groups. Patients showed higher IgG (P = 0.0025) and IgA (P = 0.0372) antibody levels to TSST-1 than normal spouses and these responses were not related to rheumatoid factor titres or HLA-DR type. CONCLUSION: When compared to normals, rheumatoid arthritis patients more often carry S aureus in their nasal vestibule, carry a distinct subpopulation of S aureus strains, and have higher average antibody levels to TSST-1.
D Tabarya; W L Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  55     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-09     Completed Date:  1997-01-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  823-8     Citation Subset:  IM    
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
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MeSH Terms
Aged, 80 and over
Antibodies, Bacterial / blood
Arthritis, Rheumatoid / immunology,  microbiology*
Bacterial Toxins*
Enterotoxins / immunology*
Escherichia coli / immunology
HLA-DR Antigens / blood,  genetics
Immunoglobulin A / blood
Immunoglobulin G / blood
Middle Aged
Nose / microbiology*
Staphylococcus aureus / immunology,  isolation & purification*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Toxins; 0/Enterotoxins; 0/HLA-DR Antigens; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Superantigens; 0/enterotoxin F, Staphylococcal; 37337-57-8/enterotoxin A, Staphylococcal

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