| Staphylococcus aureus nasal carriage in patients on haemodialysis: role of cutaneous colonization. | |
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MedLine Citation:
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PMID: 15350709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a prospective study of Staphylococcus aureus nasal carriage in patients on chronic haemodialysis to determine the role of cutaneous colonization in the aetiology of recurrent nasal colonization. From February 2000 to September 2001, 71 patients on chronic haemodialysis in the dialysis unit at a university hospital were screened monthly for S. aureus nasal carriage. Carriers received nasal mupirocin for five days and were tested for nasal and cutaneous carriage two days later and monthly thereafter. Using genotyping results, recurrence was defined as relapse if pretreatment and subsequent nasal isolates were clonally identical; if the isolates were different, it was considered recolonization. Thirty-nine patients (55%) were nasal carriers: 11 initially and 28 during follow-up. Among the mupirocin-treated patients, the eradication of S. aureus nasal carriage rate was 88.5%. Nasal recurrence was documented in 17 patients (43.5%), and S. aureus nasal strains were available for molecular typing in 14 patients with a total of 23 recurrence episodes. On the basis of pulsed-field gel electrophoresis analysis, 16 (70%) recurrence episodes were considered relapses and seven were considered (30%) recolonizations. Among the episodes of relapse, prior cutaneous colonization was detected in only three cases. In haemodialysis patients, the majority of nasal carriage recurrences after mupirocin therapy were due to relapses. Cutaneous colonization does not appear to be relevant in the development of these relapses. |
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Authors:
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C Peña; N Fernández-Sabe; M A Domínguez; M Pujol; A Martinez-Castelao; J Ayats; F Gudiol; J Ariza |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of hospital infection Volume: 58 ISSN: 0195-6701 ISO Abbreviation: J. Hosp. Infect. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2004-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007166 Medline TA: J Hosp Infect Country: England |
Other Details:
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Languages: eng Pagination: 20-7 Citation Subset: IM |
Affiliation:
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Infectious Diseases Service, Hospital Universitari de Bellvitge, c/Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. cpena@csub.scs.es |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use Carrier State / epidemiology* Female Follow-Up Studies Humans Male Middle Aged Mupirocin / therapeutic use Nose Diseases / epidemiology*, prevention & control Recurrence Renal Dialysis* Skin Diseases / epidemiology*, prevention & control Spain / epidemiology Staphylococcal Infections / epidemiology*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 12650-69-0/Mupirocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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