| Staphylococcus aureus meningitis: experience with cefuroxime treatment during a 16 year period in a Danish region. | |
| | |
MedLine Citation:
|
PMID: 12875516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Staphylococcus aureus is a rare cause of bacterial meningitis and there is no consensus on antibiotic treatment. Nafcillin is a common choice in countries where it is approved and marketed. High-dose cefuroxime has been the systemic treatment used in the study region, and a retrospective record review was conducted to determine its clinical efficacy. Cases of bacterial meningitis during 1984-1999 in the County of North Jutland, Denmark (approx. 490000 inhabitants), were identified in a regional bacteriology register. Inclusion of a case required either growth of S. aureus from > or = 2 specimens of cerebrospinal fluid (CSF), 1 positive CSF specimen with a CSF leucocyte count > 10(8)/l or 1 positive CSF specimen with a concurrent positive blood culture. A diagnosis of brain abscess required growth of S. aureus from aspirated pus. Staphylococcus aureus meningitis was confirmed in 45 patients, and 5 additional patients had a brain abscess. 44 cases were nosocomial (mortality 16%) and 6 were community acquired (mortality 83%). None of the isolates was methicillin resistant and 6 were penicillin susceptible. Intraventricular antibiotic treatment was given to 28 patients, systemic therapy included cefuroxime in 32 patients (64%) as either a primary or secondary choice, 6 (12%) were treated with penicillin G, 10 (20%) with penicillinase-resistant penicillin and 2 (4%) with cephalothin. Among 31 nosocomial cases treated systemically with cefuroxime the mortality was 10% (95% exact confidence limits 2-26%). In conclusion, cefuroxime seems to be a valid choice for S. aureus meningitis in the nosocomial setting. |
| | |
Authors:
|
Mette Nørgaard; Gudrun Gudmundsdottir; Carsten Schade Larsen; Henrik Carl Schønheyder |
Related Documents
:
|
17822846 - Levels of apoe in cerebrospinal fluid are correlated with tau and 24s-hydroxycholestero... 22473096 - Treatment selection in metastatic renal cell carcinoma: expert consensus. 22897916 - Dasatinib in chronic myeloid leukemia: a limited indian experience. 15835286 - Fatal meningoencephalitis caused by disseminated strongyloidiasis. 7250696 - Social characteristics of a hemophilia clinic population. a survey and literature review. 15028896 - Workload and case-mix in a greek emergency department. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of infectious diseases Volume: 35 ISSN: 0036-5548 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2003 |
Date Detail:
|
Created Date: 2003-07-23 Completed Date: 2003-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: Sweden |
Other Details:
|
Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
|
Department of Medical Haematology, Aalborg Hospital, Aalborg, Denmark. m.noergaard@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Cefuroxime / administration & dosage* Child Child, Preschool Cross Infection / diagnosis, drug therapy, epidemiology Denmark / epidemiology Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Infant Male Meningitis, Bacterial / diagnosis, drug therapy*, epidemiology Middle Aged Retrospective Studies Staphylococcal Infections / diagnosis, drug therapy*, epidemiology Staphylococcus aureus / drug effects, isolation & purification* Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
55268-75-2/Cefuroxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morbidity, mortality and clinical presentation of nursing home-acquired pneumonia in a Swedish popul...
Next Document: Role of genital mycoplasmata and other bacteria in urolithiasis.