Document Detail

The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.
MedLine Citation:
PMID:  12438444     Owner:  NLM     Status:  MEDLINE    
Staphylococcus aureus (SA) is an opportunistic pathogen that affects a variety of organ systems and is responsible for many diseases worldwide. SA express an MHC class II analog protein (Map), which may potentiate SA survival by modulating host immunity. We tested this hypothesis in mice by generating Map-deficient SA (Map(-)SA) and comparing disease outcome to wild-type Map(+)SA-infected mice. Map(-)SA-infected mice presented with significantly reduced levels of arthritis, osteomyelitis, and abscess formation compared with control animals. Furthermore, Map(-)SA-infected nude mice developed arthritis and osteomyelitis to a severity similar to Map(+)SA-infected controls, suggesting that T cells can affect disease outcome following SA infection and Map may attenuate cellular immunity against SA. The capacity of Map to alter T cell function was tested more specifically in vitro and in vivo using native and recombinant forms of Map. T cells or mice treated with recombinant Map had reduced T cell proliferative responses and a significantly reduced delayed-type hypersensitivity response to challenge antigen, respectively. These data suggest a role for Map as an immunomodulatory protein that may play a role in persistent SA infections by affecting protective cellular immunity.
Lawrence Y Lee; Yuko J Miyamoto; Bradley W McIntyre; Magnus Höök; Kirk W McCrea; Damien McDevitt; Eric L Brown
Related Documents :
22772754 - Human atp-binding cassette g1 controls macrophage lipoprotein lipase bioavailability an...
11849314 - Influence of cd4 t cells and the source of major histocompatibility complex class ii-re...
24570844 - Physico-chemical factors influencing autologous conditioned serum purification.
23585364 - Blood pro-inflammatory cytokines in alzheimer's disease in relation to the use of acety...
10873154 - Type v collagen modulates alloantigen-induced pathology and immunology in the lung.
9755104 - Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothel...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  110     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-19     Completed Date:  2003-01-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1461-71     Citation Subset:  AIM; IM; S    
The Center for Extracellular Matrix Biology, Texas A&M University System Health Science Center, Albert B. Alkek Institute of Biosciences and Technology, Houston, Texas 77030-7552, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / pharmacology
Adoptive Transfer
Arthritis, Infectious / etiology,  immunology,  pathology
Bacterial Proteins / genetics,  immunology*,  pharmacology
Hypersensitivity, Delayed
Immunity, Cellular
Lymphocyte Activation
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Nude
Osteomyelitis / etiology,  immunology,  pathology
Recombinant Proteins / genetics,  pharmacology
Staphylococcal Infections / immunology,  microbiology
Staphylococcus aureus / genetics,  immunology*,  pathogenicity
T-Lymphocytes / immunology*
Grant Support
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Bacterial Proteins; 0/Map protein, Staphylococcus aureus; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.
Next Document:  Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.