Document Detail


The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.
MedLine Citation:
PMID:  12438444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Staphylococcus aureus (SA) is an opportunistic pathogen that affects a variety of organ systems and is responsible for many diseases worldwide. SA express an MHC class II analog protein (Map), which may potentiate SA survival by modulating host immunity. We tested this hypothesis in mice by generating Map-deficient SA (Map(-)SA) and comparing disease outcome to wild-type Map(+)SA-infected mice. Map(-)SA-infected mice presented with significantly reduced levels of arthritis, osteomyelitis, and abscess formation compared with control animals. Furthermore, Map(-)SA-infected nude mice developed arthritis and osteomyelitis to a severity similar to Map(+)SA-infected controls, suggesting that T cells can affect disease outcome following SA infection and Map may attenuate cellular immunity against SA. The capacity of Map to alter T cell function was tested more specifically in vitro and in vivo using native and recombinant forms of Map. T cells or mice treated with recombinant Map had reduced T cell proliferative responses and a significantly reduced delayed-type hypersensitivity response to challenge antigen, respectively. These data suggest a role for Map as an immunomodulatory protein that may play a role in persistent SA infections by affecting protective cellular immunity.
Authors:
Lawrence Y Lee; Yuko J Miyamoto; Bradley W McIntyre; Magnus Höök; Kirk W McCrea; Damien McDevitt; Eric L Brown
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  110     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-19     Completed Date:  2003-01-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1461-71     Citation Subset:  AIM; IM; S    
Affiliation:
The Center for Extracellular Matrix Biology, Texas A&M University System Health Science Center, Albert B. Alkek Institute of Biosciences and Technology, Houston, Texas 77030-7552, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology
Adoptive Transfer
Animals
Apoptosis
Arthritis, Infectious / etiology,  immunology,  pathology
Bacterial Proteins / genetics,  immunology*,  pharmacology
Hypersensitivity, Delayed
Immunity, Cellular
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Nude
Osteomyelitis / etiology,  immunology,  pathology
Recombinant Proteins / genetics,  pharmacology
Staphylococcal Infections / immunology,  microbiology
Staphylococcus aureus / genetics,  immunology*,  pathogenicity
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
AI-20624/AI/NIAID NIH HHS; CA-62596/CA/NCI NIH HHS; CA09598/CA/NCI NIH HHS; CCU618387/CC/CDC HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Bacterial Proteins; 0/Map protein, Staphylococcus aureus; 0/Recombinant Proteins
Comments/Corrections

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