Document Detail


Staphylococcal and streptococcal superantigen exotoxins.
MedLine Citation:
PMID:  23824366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.
Authors:
Adam R Spaulding; Wilmara Salgado-Pabón; Petra L Kohler; Alexander R Horswill; Donald Y M Leung; Patrick M Schlievert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinical microbiology reviews     Volume:  26     ISSN:  1098-6618     ISO Abbreviation:  Clin. Microbiol. Rev.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-04     Completed Date:  2014-01-13     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  8807282     Medline TA:  Clin Microbiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Exotoxins / chemistry,  immunology*
Humans
Models, Molecular
Staphylococcal Infections / microbiology
Staphylococcus aureus / immunology*
Streptococcal Infections / microbiology
Streptococcus pyogenes / immunology*
Superantigens / chemistry,  immunology*
Grant Support
ID/Acronym/Agency:
P01 AI083211/AI/NIAID NIH HHS; R01 AI074283/AI/NIAID NIH HHS; R01 AR041256/AR/NIAMS NIH HHS; R01 AR41256/AR/NIAMS NIH HHS; U54 AI57153/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Exotoxins; 0/Superantigens
Comments/Corrections

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