Document Detail

Staphylococcal scalded skin syndrome: potentiation by immunosuppression in mice; toxin-mediated exfoliation in a healthy adult.
MedLine Citation:
PMID:  4822864     Owner:  NLM     Status:  MEDLINE    
Staphylococcal scalded skin syndrome, associated with exfoliative toxin produced by phage group II Staphylococcus aureus, has recently been reported in an adult receiving immunosuppressive therapy. To determine the effect of immunosuppression on the development of the staphylococcal scalded skin syndrome, experimental animals were treated with prednisolone, azathioprine, or a combination of both drugs utilizing the clinical isolate from the adult with scalded skin syndrome. The mean lethal dose and mean exfoliating dose were identical and were 6,000-fold lower in animals receiving both drugs or azathioprine alone. The isolate was not more virulent and did not produce more toxin than other group II phage-type strains. Furthermore, immunosuppressive therapy failed to enhance the susceptibility of experimental animals to a purified preparation of toxin. Finally, purified exfoliative toxin was demonstrated to produce erythema, Nikolsky's sign, bullous formation, and flaking desquamation in a normal human adult. The results demonstrated the enhanced susceptibility of experimental animals receiving immunosuppressive therapy to the development of the staphylococcal scalded skin syndrome. They further showed that human adults are susceptible to the action of exfoliative toxin and suggested that, in the host with compromised defense mechanisms, toxin-producing strains may invade and initiate infection resulting in toxin production and exfoliation.
B B Wiley; S Allman; M Rogolsky; C W Norden; L A Glasgow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  9     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1974 Apr 
Date Detail:
Created Date:  1974-06-14     Completed Date:  1974-06-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-40     Citation Subset:  IM    
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MeSH Terms
Azathioprine / pharmacology
Bacteriophage Typing
Lethal Dose 50
Prednisolone / pharmacology
Skin Diseases, Infectious / microbiology*
Skin Manifestations
Staphylococcus / drug effects,  isolation & purification*
Toxins, Biological / biosynthesis*
Reg. No./Substance:
0/Toxins, Biological; 446-86-6/Azathioprine; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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