| Staphylococcal scalded skin syndrome: loss of desmoglein 1 in patient skin. | |
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MedLine Citation:
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PMID: 20558334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococcal scalded skin syndrome (SSSS) is a blistering disease of the skin caused by an infection with certain strains of Staphylococcus aureus. In vitro studies have suggested that exfoliative toxins secreted by these bacteria cleave the desmosomal adhesion molecule desmoglein 1 leading to loss of cell-cell contact in the superficial epidermis. In this study we investigated the fate of desmoglein 1 in biopsies of patients with SSSS to see whether the ectodomain of desmoglein 1 is cleaved. Our data largely confirm previous in vitro data. The different biopsies demonstrated the loss of the ectodomain of desmoglein 1 to different degrees. The endodomain of desmoglein 1 meanwhile remained present. Most remarkably, in one of our patients, the immunofluorescent analysis demonstrated that not desmoglein1 but desmocollin 1, another desmosomal cadherin, became affected. This raises the question if other toxins and/or other bacteria than Staphylococcus aureus might also induce SSSS. |
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Authors:
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A Susanne Aalfs; D A Mira Oktarina; Gilles F H Diercks; Marcel F Jonkman; Hendri H Pas |
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Publication Detail:
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Type: Journal Article Date: 2010-06-17 |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: 20 ISSN: 1167-1122 ISO Abbreviation: Eur J Dermatol Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: France |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
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Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Biopsy Child Child, Preschool Desmoglein 1 / metabolism* Exfoliatins / metabolism Female Humans Infant Infant, Newborn Male Microscopy, Fluorescence Staphylococcal Scalded Skin Syndrome / metabolism*, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Desmoglein 1; 0/Exfoliatins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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