Document Detail

Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.
MedLine Citation:
PMID:  23667836     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.
OBJECTIVE: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.
METHODS: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.
RESULTS: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).
CONCLUSION: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.
Woo-Jung Song; Eun-Jung Jo; Ji-Won Lee; Hye-Ryun Kang; Sang-Heon Cho; Kyung-Up Min; Yoon-Seok Chang
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Publication Detail:
Type:  Journal Article     Date:  2013-04-26
Journal Detail:
Title:  Asia Pacific allergy     Volume:  3     ISSN:  2233-8276     ISO Abbreviation:  Asia Pac Allergy     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-05-14     Revised Date:  2013-05-17    
Medline Journal Info:
Nlm Unique ID:  101561954     Medline TA:  Asia Pac Allergy     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  120-6     Citation Subset:  -    
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.
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