Document Detail


Staphylococcal enterotoxin B up-regulates interleukin-2 receptor beta chain expression on tonsillar B cells.
MedLine Citation:
PMID:  8405068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The superantigen staphylococcal enterotoxin B (SEB) selectively up-regulates the interleukin-2 receptor (IL-2R) beta chain (p70) without up-regulating the IL-2R alpha chain (CD25) on a human tonsillar B cell population depleted of T cells. This action of SEB, probably mediated by binding to major histocompatibility complex class II, renders B cells sensitive to T cell-derived IL-2 and is sufficient for induction of vigorous DNA synthesis with low concentrations of IL-2. This explains one of the mechanisms by which bacterial superantigens activate large numbers of B cells and may reflect a similar mechanism operative in cognate helper T cell/B cell interactions.
Authors:
A Franz; A Bryant; J Farrant
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  23     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-12     Completed Date:  1993-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  2696-9     Citation Subset:  IM    
Affiliation:
Immunodeficiency Diseases Research Group, Clinical Research Centre, Harrow, GB.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
B-Lymphocytes / drug effects*,  immunology,  metabolism
Child
DNA / biosynthesis
Enterotoxins / pharmacology*
HLA-D Antigens / metabolism
Humans
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism
Interleukin-2 / pharmacology
Lymphocyte Activation
Receptors, Interleukin-2 / drug effects,  metabolism*
Staphylococcus aureus / immunology
Superantigens
Up-Regulation
Chemical
Reg. No./Substance:
0/Enterotoxins; 0/HLA-D Antigens; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Interleukin-2; 0/Receptors, Interleukin-2; 0/Superantigens; 39424-53-8/enterotoxin B, staphylococcal; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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