Document Detail

Staphylococcal bacteremia in cancer patients: intravenous and oral antimicrobial therapy.
MedLine Citation:
PMID:  7036355     Owner:  NLM     Status:  MEDLINE    
Eighteen adult cancer patients with 21 episodes of staphylococcal bacteremia were treated with sequential intravenous and oral antimicrobial agents. Adequacy of antimicrobial therapy was monitored with serum antibacterial activity studies. The mean duration of intravenous and oral therapy was nine and 25 days, respectively. Clinical and bacteriologic cures were achieved in all cases except one, in which relapse occurred after only 16 days of therapy. One patient had staphylococcal endocarditis and one had staphylococcal pneumonia. Four patients died of causes unrelated to staphylococcal bacteremia after 12, 21, 27, and 40 days of therapy, respectively. Initial intravenous therapy followed by oral antimicrobial agents to complete treatment, monitored with serum antibacterial activity studies, is effective therapy for patients with cancer and staphylococcal bacteremia.
D N Carney; R H Parker; B E Fossieck
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  75     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Cefazolin / administration & dosage
Cephalexin / administration & dosage
Cephalosporins / administration & dosage*
Cephalothin / administration & dosage
Clinical Trials as Topic
Dicloxacillin / administration & dosage
Injections, Intravenous
Microbial Sensitivity Tests
Nafcillin / administration & dosage*
Neoplasms / complications*
Sepsis / complications,  drug therapy*
Staphylococcal Infections / complications,  drug therapy*
Reg. No./Substance:
0/Cephalosporins; 147-52-4/Nafcillin; 153-61-7/Cephalothin; 15686-71-2/Cephalexin; 25953-19-9/Cefazolin; 3116-76-5/Dicloxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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