Document Detail

Staphylococcal enterocolitis: forgotten but not gone?
MedLine Citation:
PMID:  19609675     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Staphylococcus aureus may cause antibiotic-associated diarrhea and enterocolitis, with or without preceding antibiotic use, in immunocompromised adults or infants, or individuals with predisposing conditions, but there is little appreciation of this condition clinically. CLINICAL DISEASE: The main clinical feature that helps to differentiate staphylococcal enterocolitis (SEC) from Clostridium difficile-associated diarrhea is large-volume, cholera-like diarrhea in the former case. A predominance of gram-positive cocci in clusters on gram stain of stool or biopsy specimens and the isolation of S. aureus as the dominant or sole flora support the diagnosis. PATHOGENESIS: The pathogenesis of SEC requires the interaction of staphylococcal enterotoxins, which function as superantigens, with interstitial epithelial lymphocytes and intestinal epithelial cells (IECs). MANAGEMENT: Most SEC represents recent S. aureus acquisition, so that improved infection prevention practices can reduce disease recurrence. Management should include aggressive fluid management and repletion and oral vancomycin.
Zheng Lin; Donald P Kotler; Patrick M Schlievert; Emilia Mia Sordillo
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-16
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1200-7     Citation Subset:  AIM; IM    
Division of Gastroenterology, Department of Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Diagnosis, Differential
Enterocolitis / diagnosis*,  immunology,  microbiology*,  therapy*
Fluid Therapy
Staphylococcal Infections / diagnosis*,  immunology,  therapy*
Vancomycin / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 1404-90-6/Vancomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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