| Stannous fluoride/sodium hexametaphosphate dentifrice increases dentin resistance to tubule exposure in vitro. | |
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MedLine Citation:
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PMID: 17508625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to compare the reactivity of three dentifrice formulations on smear layer-covered root dentin surfaces, and the effects of the formulation treatments on resistance to acid softening and dentinal tubuli disclosure. METHODOLOGY: Commercial dentifrices, including Crest Cavity Protection Regular, Colgate Total, and a new dentifrice comprised of stannous fluoride/sodium hexametaphosphate (SnF2/HMP: Crest Pro-Health), were cycled through a pre-treatment period on smear layer-covered dentin surfaces, including intermittent soaking in dentifrice slurries and whole human saliva immersion. Following pre-treatments, the cycling treatments were modified to include dietary acid exposure, including soaks in an acidic soft drink. Vickers surface microhardness, variable pressure scanning electron microscopy (VP-SEM), and confocal laser scanning microscopy in reflection mode (CLSM) were used to characterize dentin reactivity and smear layer protection. RESULTS: CLSM and SEM analyses showed that specimens treated with SnF2/HMP appeared to resist acid solubilization, evidenced by the absence of disclosed dentinal tubuli. The histo-tomographic observations in this study were in agreement with the hardness measurements. The superior surface protection of dentin with SnF2/HMP would suggest potential benefits in ameliorating dentinal hypersensitivity in the clinical situation. CONCLUSION: A stannous fluoride/sodium hexametaphosphate dentifrice prevents dietary acid softening and tubule exposure of smear layer dentin surfaces. |
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Authors:
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Donald J White; Michelle A Lawless; Ayowumi Fatade; Arif Baig; Roxana von Koppenfels; Heinz Duschner; Hermann Götz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical dentistry Volume: 18 ISSN: 0895-8831 ISO Abbreviation: J Clin Dent Publication Date: 2007 |
Date Detail:
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Created Date: 2007-05-18 Completed Date: 2007-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904411 Medline TA: J Clin Dent Country: United States |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: D |
Affiliation:
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Procter & Gamble Health Care Research Center, Mason, Ohio, USA. White.dj.1@pg.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dentifrices
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chemistry,
pharmacology,
therapeutic use* Dentin Sensitivity / prevention & control* Dentin Solubility / drug effects* Drug Combinations Hardness Humans Microscopy, Confocal Microscopy, Electron, Scanning Phosphates / pharmacology, therapeutic use* Smear Layer Tin Fluorides / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Dentifrices; 0/Drug Combinations; 0/Phosphates; 0/Tin Fluorides; 10124-56-8/sodium polymetaphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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