Document Detail

Standards for dysmorphological diagnosis in human fetuses.
MedLine Citation:
PMID:  14708736     Owner:  NLM     Status:  MEDLINE    
This study provides new standards for some fetal dimensions frequently concerned with dysmorphological syndromes. Seven dimensions were included: the outer and inner canthal distances (OCD and ICD), the anteroposterior and transversal ocular diameters, the biparietal diameter and head circumference, and the inter-nipple distance. Subjects came from a large data set including more than 4000 fetuses autopsied in fetopathology units of pediatric hospitals in Paris between 1986 and 2001. From this data set, 673 subjects were carefully selected by exclusion of multiple pregnancies, macerated and malformed fetuses, and subjects with abnormal karyotypes and severe infections. Fetal ages ranged from 11 to 42 gestational wk, with a very large sample of fetuses in the first half of gestation. The standards of each dimension were computed in relation to age, as well as the ratio ICD/OCD. The mathematical models used to fit the percentile growth curves were carefully selected for each variable. This study supplies a set of accurate standards of specific dimensions useful for dysmorphological diagnosis in fetuses.
Anne-Marie Guihard-Costa; F Menez; A L Delezoide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  6     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-34     Citation Subset:  IM    
Unité Propre de Recherche (UPR) 2147, Centre National de la Recherche Scientifique (CNRS), 44 Rue de l'Amiral Mouchez, 75014 Paris, France.
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MeSH Terms
Congenital Abnormalities / diagnosis*
Fetus / abnormalities*,  embryology*
Gestational Age
Pathology / methods*,  standards
Reference Standards

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