Document Detail

Standardizing and predicting results from cardiopulmonary exercise testing in patients with heart failure.
MedLine Citation:
PMID:  17135859     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Cardiopulmonary exercise testing is a common prognostic tool in heart failure, yet it is not standardized. The purpose of this study was to evaluate a means of standardizing oxygen consumption (VO(2)) measurement and to evaluate the ability to predict peak VO(2) from submaximal exercise. METHODS: Fifty consecutive exercise tests with a respiratory exchange ratio > or =1.10 were evaluated. VO(2) was graphed against respiratory exchange ratio and the peak VO(2) was determined with logarithmic, linear, power, and exponential regression lines. To predict a peak VO(2), each patient's submaximal exercise data (respiratory exchange ratio < or =0.98) were fitted to each regression line. The mean of the last 30 seconds of un-averaged breath-by-breath data was used as the reference value. Peak VO(2) assessments are also provided from the metabolic cart, a rolling time average, and the graphical method. RESULTS: Logarithmic regression best standardized peak VO(2). Mean absolute bias (mL x kg x min) was 0.60 +/- 0.44 for logarithmic, 0.61 +/- 0.47 for linear, 0.85 +/- 0.67 for power, and 1.44 +/- 2.22 for exponential. The mean absolute bias between the peak logarithmic predicted VO(2) and the reference peak VO(2) was 1.62 +/- 1.20 mL x kg x min (9.5% of the peak VO(2)). CONCLUSION: Among the methods studied, logarithmic regression analysis was the best method to standardize and predict peak VO(2) in this cohort of patients with heart failure.
Robert L Bard; John M Nicklas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation     Volume:  26     ISSN:  0883-9212     ISO Abbreviation:  J Cardiopulm Rehabil     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-11-30     Completed Date:  2007-03-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511296     Medline TA:  J Cardiopulm Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  384-90     Citation Subset:  IM    
University of Michigan Medical Center, Ann Arbor, MI 48106, USA.
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MeSH Terms
Exercise Test / standards*
Heart Failure / physiopathology*
Middle Aged
Oxygen Consumption / physiology*
Pulmonary Gas Exchange / physiology
Regression Analysis

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