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Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer.
MedLine Citation:
PMID:  20039074     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: Phase angle (PA), determined by bioelectrical impedance analysis (BIA), has been considered as a prognostic factor in several clinical conditions. The purpose of this study is to investigate PA, after adjusting for sex and age (standardized phase angle; SPA) as a prognostic factor for survival in cancer patients.
METHODS: A prospective study was conducted in 195 patients before the first chemotherapy course. BIA was performed in all patients and SPA was calculated. The Kaplan-Meier method was used to calculate survival. The Cox regression method was used to evaluate the independent prognostic effect of PA after adjustment for other variables.
RESULTS: Patients with SPA < -1.65 had a smaller survival rate than those with SPA ≥ -1.65 (p < 0.001). Using Cox regression, the mortality rate was higher in patients with SPA < -1.65 (RR 3.12 CI: 2.03-4.79; p < 0.001). After multivariate analysis, patients with PA < -1.65 still presented a higher mortality rate (RR 2.35 CI: 1.41-3.90; p = 0.001).
CONCLUSIONS: The present study demonstrates that PA, used as SPA, is an independent prognostic indicator in this group of cancer patients receiving chemotherapy treatment even after adjustment for other prognostic variables.
Silvana Iturriet Paiva; Lúcia R Borges; Denise Halpern-Silveira; M Cecília F Assunção; Aluisio J D Barros; M Cristina Gonzalez
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Publication Detail:
Type:  Journal Article     Date:  2009-12-29
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  19     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Post-graduate Program, Health and Behaviour, Catholic University of Pelotas, Rua Porto Alegre, 492, 96090-520, Pelotas, RS, Brazil,
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