Document Detail

Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients.
MedLine Citation:
PMID:  18274987     Owner:  NLM     Status:  MEDLINE    
Studies of the standardized, 3D, 16-segments map of the circumferential distribution of T2* values, of cardiovascular magnetic resonance (CMR) in thalassemia major (TM) and thalassemia intermedia (TI) patients and of electrocardiogram (ECG) changes associated with TM, have been carried out. Similarly, the segment-dependent correction map of the T2* values and the artifactual variations in normal subjects and the T2* correction map to correct segmental measurements in patients with different levels of myocardial iron burden have been evaluated. Cardiovascular magnetic resonance can be a suitable guide to cardiac management in TI, as well as in TM; TI patients show lower myocardial iron burden and more pronounced high cardiac output findings than TM patients. Moreover, it is proposed that, due to its good positive predictive value (PPV) and low cost, ECG can be a suitable guide to orient towards CMR examination in TM cases.
Anna Ramazzotti; Alessia Pepe; Vincenzo Positano; Barbara Scattini; Maria F Santarelli; Luigi Landini; Daniele De Marchi; Petra Keilberg; Giorgio Derchi; Francesco Formisano; Marcello Pili; Maria E Lai; Gianluca Forni; Aldo Filosa; Luciano Prossomariti; Marcello Capra; Lorella Pitrolo; Caterina Borgna-Pignatti; Paolo Cianciulli; Aurelio Maggio; Massimo Lombardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hemoglobin     Volume:  32     ISSN:  0363-0269     ISO Abbreviation:  Hemoglobin     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-107     Citation Subset:  IM    
Magnetic Resonance Imaging Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy.
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MeSH Terms
Electrocardiography / methods*
Iron Overload / complications,  diagnosis*
Magnetic Resonance Imaging / methods*
Myocardium / metabolism,  pathology*
Thalassemia / complications,  diagnosis*,  metabolism,  pathology

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