| Standardized MR protocol for the evaluation of MRA sequences and/or contrast agents effects in high-degree arterial stenosis analysis. | |
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MedLine Citation:
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PMID: 12098569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the relative role of high resolution (spatial or temporal) magnetic resonance angiography (MRA) sequence and of contrast agent properties in the evaluation of high-degree arterial stenosis. METHODS: We qualitatively and quantitatively studied both 50 and 95% (300 microm diameter) stenosis of a 6 mm arterial phantom with two contrast agents (CA), Gd-DOTA (r(1)=2.9 mM(-1) s(-1)) versus P760 (r(1)=25 mM(-1) s(-1)) at several CA concentrations, including arterial peak concentration after injection of either a single or double dose of CA, using either a high temporal (booster) or high spatial (HR) resolution 3D MRA sequences. Experimental data were then compared to theoretical data. RESULTS: With the 3D HR sequence, both visual and quantitative analysis were significantly better compared to the 3D booster sequence, at each phantom diameter. Quantitative analysis was significantly improved by injection of a double versus a single dose of each CA (Gd-DOTA or P760), primarily in high degree stenosis. CONCLUSION: Combined MRA spatial resolution and high CA efficiency are mandatory to correctly evaluate high degree stenosis. |
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Authors:
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Bruno Marchand; Philippe C Douek; Philippe Robert; Claire Corot; Jean Pierre Roux; Patrice Adeleine; Marcela Hernandez-Hoyos; Yannick Cremillieux; Maciej Orkisz; Emmanuelle Canet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magma (New York, N.Y.) Volume: 14 ISSN: 0968-5243 ISO Abbreviation: MAGMA Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-05 Completed Date: 2003-01-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9310752 Medline TA: MAGMA Country: Netherlands |
Other Details:
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Languages: eng Pagination: 259-67 Citation Subset: IM |
Affiliation:
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Laboratoire Creatis, UMR 5515, INSA 502, 69621 Vileurbanne, France. bruno.marchand@voila.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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diagnosis* Arteries / anatomy & histology, pathology Constriction, Pathologic / diagnosis Dose-Response Relationship, Drug Heterocyclic Compounds / diagnostic use* Humans Magnetic Resonance Angiography / instrumentation*, methods*, standards Models, Cardiovascular* Organometallic Compounds / diagnostic use* Phantoms, Imaging Quality Control Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Heterocyclic Compounds; 0/Organometallic Compounds; 0/gadolinium compound P760; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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