| Standardization of thromboelastography: a report from the TEG-ROTEM working group. | |
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MedLine Citation:
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PMID: 21323795 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Summary. Laboratory evaluation of bleeding disorders has been performed with the standard clotting assays such as the PT and PTT for several decades. Our improved understanding of the process of blood coagulation has now revealed the important role played by the cellular elements such as platelets, monocytes and red blood cells. The need for a test that can assess clotting in a more 'global' manner, beyond the initiation of clot formation, has led to greater interest in assays such as thrombin generation and thromboelastography. Even though there are several publications using thromboelastography it remains a research tool as the methodology is not standardized. In an attempt to show reproducibility and consistency using thromboelastography, a group of investigators from different countries joined hands to form the TEG-ROTEM Working Group. Two studies were performed using PRP and FVIII deficient plasma and an intrinsic pathway activator. This article summarizes the results of the first international effort at standardization of thromboelastography. Both of the instruments using this technology (TEG(®) and ROTEM(®) ) were used. Nine laboratories from countries around the globe participated in this effort. The results showed a significant inter-laboratory variance with CV's greater than 10%. Although these results were not satisfactory, this has been the first effort to standardize this methodology and significant work remains to be done to improve reliability and reproducibility. These studies were performed on PRP and the results may be more reliable when preformed on whole blood samples. We believe that it is important to continue this work so that we may investigate the usefulness and potential applications of thromboelastography in the evaluation of bleeding and thrombosis. |
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Authors:
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M Chitlur; B Sorensen; G E Rivard; G Young; J Ingerslev; M Othman; D Nugent; G Kenet; M Escobar; J Lusher |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-15 |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: - ISSN: 1365-2516 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Hematology/Oncology, Carman and Ann Adams Department of Pediatrics, Wayne State University/Children's Hospital of Michigan, Detroit, MI, USA Haemostasis Research Unit, Centre for Haemostasis & Thrombosis, Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK Division of Hematology, Hospital Ste Justine, Montreal, QC, Canada Department of Hematology/Oncology, Childrens Hospital Los Angeles, Los Angeles, CA, USA Center for Hemophilia and Thrombosis, Department of Biochemistry, University Hospital Skejby, Aarhus, Denmark Department of Pathology and Molecular Medicine, Queens University, Kingston, ON, Canada Division of Hematology, Children's Hospital of Orange County, Orange, CA, USA Thrombosis Unit, The National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel Gulf States Hemophilia and Thrombophilia Center, University of Texas Health Science Center at Houston, Houston, TX, USA Hemostasis-Thrombosis Program and Coagulation Labs, Division of Hematology/Oncology, Department of Pediatrics, Marion I. Barnhart Chair in Hemostasis Research, Wayne State University, Children's Hospital of Michigan, Detroit, MI, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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