| Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative. | |
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MedLine Citation:
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PMID: 22047631 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Numerous studies show that the cerebrospinal fluid biomarkers total tau (T-tau), tau phosphorylated at threonine 181 (P-tau(181P)), and amyloid-β (1-42) (Aβ(1-42)) have high diagnostic accuracy for Alzheimer's disease. Variability in concentrations for Aβ(1-42), T-tau, and P-tau(181P) drives the need for standardization. METHODS: Key issues were identified and discussed before the first meeting of the members of the Alzheimer's Biomarkers Standardization Initiative (ABSI). Subsequent ABSI consensus meetings focused on preanalytical issues. RESULTS: Consensus was reached on preanalytical issues such as the effects of fasting, different tube types, centrifugation, time and temperature before storage, storage temperature, repeated freeze/thaw cycles, and length of storage on concentrations of Aβ(1-42), T-tau, and P-tau(181P) in cerebrospinal fluid. CONCLUSIONS: The consensus reached on preanalytical issues and the recommendations put forward during the ABSI consensus meetings are presented in this paper. |
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Authors:
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Hugo Vanderstichele; Mirko Bibl; Sebastiaan Engelborghs; Nathalie Le Bastard; Piotr Lewczuk; Jose Luis Molinuevo; Lucilla Parnetti; Armand Perret-Liaudet; Leslie M Shaw; Charlotte Teunissen; Dirk Wouters; Kaj Blennow |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-31 |
Journal Detail:
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Title: Alzheimer's & dementia : the journal of the Alzheimer's Association Volume: - ISSN: 1552-5279 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231978 Medline TA: Alzheimers Dement Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Innogenetics NV (now part of Fujirebio), Ghent, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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