Document Detail

Standard therapies for pulmonary arterial hypertension.
MedLine Citation:
PMID:  17338930     Owner:  NLM     Status:  MEDLINE    
After half a century of clinical experience and research, management of pulmonary arterial hypertension remains a challenge. Currently, data to support the use of standard therapies for pulmonary arterial hypertension (oxygen supplementation, diuretics, digoxin, anticoagulation, and calcium channel blockers) are mostly retrospective, uncontrolled prospective, or derived from other diseases with similar but not identical manifestations. In the absence of any further prospective, controlled studies, it is reasonable to use these therapies when they are tolerated. When these therapies are poorly tolerated, however, the threshold for discontinuation should be low.
Shoaib Alam; Harold I Palevsky
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in chest medicine     Volume:  28     ISSN:  0272-5231     ISO Abbreviation:  Clin. Chest Med.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7907612     Medline TA:  Clin Chest Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-115, viii     Citation Subset:  IM    
Division of Pulmonary, Allergy and Critical Care Medicine, Penn State University-Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Calcium Channel Blockers / therapeutic use
Diuretics / therapeutic use
Heart Failure / epidemiology,  physiopathology
Hypertension, Pulmonary / epidemiology,  physiopathology,  therapy*
Nitric Oxide / physiology
Oxygen Inhalation Therapy
Sleep Apnea, Obstructive / physiopathology
Spironolactone / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/Calcium Channel Blockers; 0/Diuretics; 10102-43-9/Nitric Oxide; 52-01-7/Spironolactone

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