Document Detail


Standard atlas of the gross anatomy of the developing inner ear of the chicken.
MedLine Citation:
PMID:  8744448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During development, the chicken inner ear undergoes a series of morphological changes which give rise to the various structures found in the adult, including the mature semicircular canals, utricle, saccule, cochlear duct, endolymphatic duct and sac, and neurons of the eighth cranial nerve ganglion. Beginning as a hollow epithelial sphere, the inner ear is sculpted into this complex labyrinth of fluid-filled ducts punctuated by their associated sensory end organs. In this report, the three-dimensional complexity of the developing inner ear of the chicken embryo is documented in the form of a standard atlas. The protocol involved fixation, dehydration, and clearing of embryonic heads harvested at daily intervals, followed by injection of an opaque dye (enamel paint suspension) into the fluid ducts of the inner ear. The position of the ear is shown relative to surface landmarks at seven different stages of development, ranging from embryonic day 5 (E5) to E18. Also shown are higher-power photomicrographs of the inner ear in isolation taken at daily intervals at E3-E17 and viewed from two orthogonal positions. Three orthogonal views are shown at 6-hour intervals during the critical stages of semicircular canal formation (E6-E7). Quantitative measurements of the linear dimensions of the inner ear (dorsoventral, anteroposterior, and mediolateral axes) as a function of time indicate a linear increase in the growth of the ear from E3 through E18. This atlas should prove valuable for evaluating mutant phenotypes in inner ear morphogenesis following gene perturbation experiments in the chicken.
Authors:
J P Bissonnette; D M Fekete
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  368     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  620-30     Citation Subset:  IM; S    
Affiliation:
Department of Biology, Boston College, Chestnut Hill, Massachusetts 02167, USA.
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MeSH Terms
Descriptor/Qualifier:
Anatomy, Artistic*
Animals
Chick Embryo / anatomy & histology*
Cochlear Duct / embryology
Ear, Inner / embryology*
Medical Illustration*
Models, Anatomic
Morphogenesis
Reference Standards
Semicircular Canals / embryology
Terminology as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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