| Staging of untreated nasopharyngeal carcinoma with PET/CT: comparison with conventional imaging work-up. | |
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MedLine Citation:
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PMID: 18704401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We prospectively compared PET/CT and conventional imaging for initial staging of nasopharyngeal carcinoma (NPC). METHODS: A total of 111 patients with histologically proven NPC were investigated with PET/CT and conventional imaging (head-and-neck MRI, chest X-ray, abdominal ultrasound, and bone scan) before treatment. The respective findings were reviewed independently and then compared with each other. RESULTS: With regard to T staging, PET/CT showed a discrepancy with head-and-neck MRI in 36 (32.4%) of the study subjects. With regard to N staging, PET/CT showed a discrepancy with head-and-neck MRI in 15 (13.5%) patients. Among the discordant cases, MRI was superior in demonstrating tumor involvement in the parapharyngeal space, skull base, intracranial area, sphenoid sinus, and retropharyngeal nodes while PET/CT was superior in demonstrating neck nodal metastasis. PET/CT disclosed 13 of 16 patients with distant malignancy compared with four patients disclosed by conventional imaging work-up. The false-positive rate of PET/CT was 18.8%. PET/CT correctly modified M staging in eight patients (7.2%) and disclosed a second primary lung malignancy in one patient (0.9%). CONCLUSION: In NPC patients, MRI appears to be superior to PET/CT for the assessment of locoregional invasion and retropharyngeal nodal metastasis. PET/CT is more accurate than MRI for determining cervical nodal metastasis and should be the better reference for the neck status. PET/CT has an acceptable diagnostic yield and a low false-positive rate for the detection of distant malignancy and can replace conventional work-up to this aim. PET/CT and head-and-neck MRI are suggested for the initial staging of NPC patients. |
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Authors:
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Shu-Hang Ng; Sheng-Chieh Chan; Tzu-Chen Yen; Joseph Tung-Chieh Chang; Chun-Ta Liao; Sheung-Fat Ko; Feng-Yuan Liu; Shu-Chyn Chin; Kang-Hsing Fan; Cheng-Lung Hsu |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-15 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 36 ISSN: 1619-7089 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2009-03-30 Revised Date: 2009-06-16 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 12-22 Citation Subset: IM |
Affiliation:
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Molecular Imaging Center and Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang Gung University, Kueishan, Taiwan. Shng6@ms25.hinet.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Lymphatic Metastasis / radiography, radionuclide imaging Magnetic Resonance Imaging Male Middle Aged Nasopharyngeal Neoplasms / diagnosis*, radiography, radionuclide imaging*, ultrasonography Neoplasm Staging / methods* Positron-Emission Tomography Tomography, X-Ray Computed |
| Comments/Corrections | |
Erratum In:
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Eur J Nucl Med Mol Imaging. 2009 Mar;36(3):538 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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