| Staging recurrent metastatic colorectal carcinoma with PET. | |
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MedLine Citation:
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PMID: 9255148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accurate detection of recurrent colorectal carcinoma remains a diagnostic challenge. The purposes of this study were to assess the accuracy of 18FDG-PET in patients with recurrent colorectal carcinoma in detecting liver metastases compared with computed tomography (CT) and CT portography, detecting extrahepatic metastases compared with CT and evaluating the impact on patient management. METHODS: Fifty-two patients previously treated for colorectal carcinoma presented on 61 occasions with suspected recurrence and underwent 18FDG-PET of the entire body. PET, CT and CT portography images were analyzed visually. The final diagnosis was obtained by pathology (n = 44) or clinical and radiological follow-up (n = 17). The impact on management was reviewed retrospectively. RESULTS: A total of 166 suspicious lesions were identified. Of the 127 intrahepatic lesions, 104 were malignant, and of the 39 extrahepatic lesions, 34 were malignant. Fluorine-18-fluorodeoxyglucose imaging was more accurate (92%) than CT and CT portography (78% and 80%, respectively) in detecting liver metastases and more accurate than CT for extrahepatic metastases (92% and 71%, respectively). Fluorine-18-fluorodeoxyglucose detected unsuspected metastases in 17 patients and altered surgical management in 28% of patients. CONCLUSION: These data identify that 18FDG-PET is the most accurate noninvasive method for staging patients with recurrent metastatic colorectal carcinoma and plays an important role in management decisions in this setting. |
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Authors:
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D Delbeke; J V Vitola; M P Sandler; R C Arildsen; T A Powers; J K Wright; W C Chapman; C W Pinson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 38 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-08 Completed Date: 1997-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1196-201 Citation Subset: IM |
Affiliation:
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Section of Nuclear Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2675, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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radiography,
radionuclide imaging*,
secondary* Algorithms Colorectal Neoplasms / pathology* Deoxyglucose / analogs & derivatives*, diagnostic use Female Fluorine Radioisotopes / diagnostic use* Fluorodeoxyglucose F18 Humans Liver Neoplasms / radiography, radionuclide imaging*, secondary* Male Middle Aged Neoplasm Staging Portography / methods Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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