| Staging performance of carbon-11 choline positron emission tomography/computed tomography in patients with bone and soft tissue sarcoma: comparison with conventional imaging. | |
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MedLine Citation:
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PMID: 16925579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to compare the diagnostic accuracy between carbon-11 choline (11C-choline) positron emission tomography (PET)/computed tomography (CT) and conventional imaging for the staging of bone and soft tissue sarcomas. Sixteen patients who underwent 11C-choline PET/CT prior to treatment were evaluated retrospectively for staging accuracy. Conventional imaging methods consisted of 99,mTc-hydroxymethylene diphosphonate bone scintigraphy, chest CT and magnetic resonance imaging of the primary site. The images were reviewed and a consensus was reached by two board-certified radiologists who were unaware of any clinical or radiological information using hard-copy films and multimodality computer platform. Tumor stage was confirmed by histological examination and/or by an obvious progression in number and/or size of the lesions on follow-up examinations. Reviewers examining both 11C-choline PET/CT and conventional imaging classified T stage in all patients. Interpretation based on 11C-choline PET/CT, the Node (N) stage was correctly diagnosed in all patients, whereas the accuracy of conventional imaging in N stage was 63%. Tumor Node Metastasis (TNM) stage was assessed correctly with 11C-choline PET/CT in 15 of 16 patients (94%) and with conventional imaging in eight of 16 patients (50%). The overall TNM staging and N staging accuracy of 11C-choline PET/CT were significantly higher than that of conventional imaging (P < 0.05). 11C-choline PET/CT is more accurate than conventional imaging regarding clinical staging of patients with bone and soft tissue sarcomas. A whole body 11C-choline PET/CT might be acceptable for imaging studies of tumor staging prior to treatment. |
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Authors:
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Ukihide Tateishi; Umio Yamaguchi; Testuo Maeda; Kunihiko Seki; Takashi Terauchi; Akira Kawai; Yasuaki Arai; Noriyuki Moriyama; Tadao Kakizoe |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cancer science Volume: 97 ISSN: 1347-9032 ISO Abbreviation: Cancer Sci. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-19 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: England |
Other Details:
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Languages: eng Pagination: 1125-8 Citation Subset: IM |
Affiliation:
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Diagnostic Radiology, Research Center for Cancer Prevention and Screening, Japan. kuenstreli@nifty.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bone Neoplasms / diagnosis*, radiography, radionuclide imaging Carbon Radioisotopes Choline / diagnostic use* Female Humans Male Middle Aged Positron-Emission Tomography Sarcoma / diagnosis*, radiography, radionuclide imaging Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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