| Staging non-small lung cancer with positron emission tomography: diagnostic value, impact on patient management, and cost-effectiveness. | |
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MedLine Citation:
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PMID: 19943430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare two preoperative staging procedures of non-small cell lung cancer (NSCLC): one using positron emission tomography (PET) and one using conventional imaging studies. Accuracy, effects on patient management, and costs were calculated. Four hundred thirteen consecutive patients with NSCLC were prospectively examined with PET and conventional imaging studies. A simulation calculated the costs of the two strategies. The accuracy of PET for metastases was 97.5% versus 84% of conventional imaging (P < 0.001). The accuracy of PET for mediastinal staging was 97%, whereas that of computed tomography was 68% (P < 0.001). The expected number of unnecessary surgeries was 24 for the conventional strategy and 8 for the PET strategy (P= 0.007). The PET strategy was less expensive. This study shows that PET is an economical tool in NSCLC staging (even in the European economic environment), with high accuracy and important management aspects. |
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Authors:
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Mario Nosotti; Massimo Castellani; Virgilio Longari; Barbara Chella; Alessandro Baisi; Lorenzo Rosso; Luigi Santambrogio |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International surgery Volume: 93 ISSN: 0020-8868 ISO Abbreviation: Int Surg Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043524 Medline TA: Int Surg Country: Italy |
Other Details:
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Languages: eng Pagination: 278-83 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy. m.nosotti@policlinico.mi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Neoplasms / secondary Carcinoma, Non-Small-Cell Lung / economics, pathology, radionuclide imaging* Cost-Benefit Analysis Decision Support Techniques Female Humans Liver Neoplasms / secondary Lung Neoplasms / economics, pathology, radionuclide imaging* Male Neoplasm Staging / methods Positron-Emission Tomography* / economics Prospective Studies Unnecessary Procedures / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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