Document Detail

Staging of advanced ovarian cancer: comparison of imaging modalities--report from the Radiological Diagnostic Oncology Group.
MedLine Citation:
PMID:  10831697     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare ultrasonography (US), magnetic resonance (MR) imaging, and computed tomography (CT) for diagnosing and staging advanced ovarian cancer. MATERIALS AND METHODS: US, CT, and MR imaging were performed in 280 patients. Images were read by three radiologists from each of the five hospitals. Image analysis included determination of malignancy within the peritoneum (11 sites), lymph nodes (10 sites), and hepatic parenchyma. The standard of reference was based on surgical and histopathologic findings. Statistical methods used were receiver operating characteristic (ROC) curve analysis, pairwise comparison of areas under the ROC curves (A(z)), analysis of sensitivity and specificity pairs, and assessment of agreement between the degree of suspicion and standard of reference. RESULTS: There were 118 patients with malignant tumors; 73 (62%) had stage III or IV disease. Metastases were found in the peritoneum in 70 (59%), nodes in 20 (17%), and liver in seven (6%) cases. In the peritoneum, MR imaging and CT (A(z) = 0.96 for both) were more accurate than US (A(z) = 0.86), especially in the subdiaphragmatic spaces and hepatic surfaces. MR imaging and CT were more sensitive than US (95%, 92%, and 69%, respectively) for peritoneal metastases. MR imaging was more accurate than CT for detection of lymph node metastases (A(z) = 0.76 vs 0.57, P =.04). In the liver, the A(z) values for the three modalities were 0.77-0.94. CONCLUSION: CT and MR imaging are equally accurate, and either modality can be used to stage advanced ovarian cancer.
C M Tempany; K H Zou; S G Silverman; D L Brown; A B Kurtz; B J McNeil
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  215     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  761-7     Citation Subset:  AIM; IM    
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Liver Neoplasms / diagnosis,  secondary
Lymphatic Metastasis
Magnetic Resonance Imaging / methods,  statistics & numerical data
Middle Aged
Neoplasm Staging
Observer Variation
Ovarian Neoplasms / diagnosis,  pathology*,  surgery
Ovary / pathology,  radiography,  ultrasonography
Prospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed / methods,  statistics & numerical data
Ultrasonography, Doppler / methods,  statistics & numerical data
United States
Grant Support
U01 CA9398-03/CA/NCI NIH HHS

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