Document Detail

Stage of chronic kidney disease and severity of coronary heart disease manifestation.
MedLine Citation:
PMID:  22332967     Owner:  NLM     Status:  In-Data-Review    
A recent study suggested that patients with chronic kidney disease (CKD) with a glomerular filtration rate (GFR) < 45 ml/min/1.73 m(2) are more likely to present with acute myocardial infarction (AMI) than with stable exertion angina. Thus, the degree of renal impairment seems to be related to the presentation of coronary heart disease (CHD). In this context, there is evidence indicating that statins decrease the excess risk for AMI and other CHD-related events in patients with CKD (although the benefit may depend on the stage of CKD). This effect might be attributed to stabilization of atherosclerotic plaques, which seem to be more vulnerable if CKD is present. Thus, statin treatment in early CKD, a condition considered to be a CHD equivalent by several guidelines, is likely to minimize the risk for CHD events.
Vasilios G Athyros; Niki Katsiki; Asterios Karagiannis; Dimitri P Mikhailidis
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Publication Detail:
Type:  Journal Article     Date:  2012-02-15
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  13     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  457-60     Citation Subset:  IM    
Aristotle University of Thessaloniki, Hippocration Hospital, Medical School, 2nd Propedeutic Department of Internal Medicine , Thessaloniki , Greece.
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