| Stage-by-Stage Effects of Surgical Margin Status on Biochemical Failure after Radical Prostatectomy in Patients with Clinically Localized Prostate Cancer. | |
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MedLine Citation:
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PMID: 21311164 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To evaluate the effects of pathological stage and surgical margin status on biochemical failure rates after radical prostatectomy (RP). Materials and Methods: The records of 205 patients who underwent RP for clinically localized prostate cancer (CaP) were evaluated. Known risk factors for biochemical failure (BF) were analyzed using univariate and multivariate logistic regression analysis. The effects of surgical margin status together with pathological stage on BF were evaluated. p values lower than 0.05 were accepted to be statistically significant. Results: Pathological stage, positive surgical margin (PSM), seminal vesicle invasion, lymph node involvement, biopsy Gleason score and postoperative Gleason score were the factors associated with BF in univariate analysis. Logistic regression analysis revealed that pT3a patients with PSM had a significant BF rate when compared to pT2 patients with a negative surgical margin (NSM) (OR 7.46, p = 0.002). pT3a patients with a NSM had a similar BF rate to that of pT2 patients with PSM. Conclusions: pT2 patients with PSM had a similar biochemical prognosis to that of pT3a patients without PSM, implicating that a PSM may have a negative effect on prognosis similar to that of extracapsular invasion. |
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Authors:
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Alp Ozgur Akdemir; Cuneyt Ozden; Cetin Volkan Oztekin; Binhan Kagan Aktas; Mesut Cetinkaya; Ali Memis; Omer Gokhan Doluoglu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-09 |
Journal Detail:
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Title: Urologia internationalis Volume: - ISSN: 1423-0399 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Clinics of Urology II, Ankara Numune Education and Research Hospital, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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