Document Detail


"Stable" ventricular tachycardia is not a benign rhythm : insights from the antiarrhythmics versus implantable defibrillators (AVID) registry.
MedLine Citation:
PMID:  11208684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sustained ventricular tachycardia (VT) can be unstable, can be associated with serious symptoms, or can be stable and relatively free of symptoms. Patients with unstable VT are at high risk for sudden death and are best treated with an implantable defibrillator. The prognosis of patients with stable VT is controversial, and it is unknown whether implantable cardioverter-defibrillator therapy is beneficial. METHODS AND RESULTS: Screening for the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial identified patients with both stable and unstable VT. Both groups were included in a registry, and their clinical characteristics and discharge treatments were recorded. Mortality data were obtained through the National Death Index. The mortality in 440 patients with stable VT tended to be greater than that observed in 1029 patients presenting with unstable VT (33.6% versus 27.6% at 3 years; relative risk [RR]=1.22; P:=0.07). After adjustment for baseline and treatment differences, the RR was little changed (RR=1.25, P:=0.06). CONCLUSIONS: Sustained VT without serious symptoms or hemodynamic compromise is associated with a high mortality rate and may be a marker for a substrate capable of producing a more malignant arrhythmia. Implantable cardioverter-defibrillator therapy may be indicated in patients presenting with stable VT.
Authors:
M H Raitt; E G Renfroe; A E Epstein; J H McAnulty; P Mounsey; J S Steinberg; S E Lancaster; R L Jadonath; A P Hallstrom;
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  103     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-52     Citation Subset:  AIM; IM    
Affiliation:
Portland VA Medical Center, Portland, Ore., USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amiodarone / therapeutic use*
Anti-Arrhythmia Agents / therapeutic use*
Controlled Clinical Trials as Topic
Defibrillators, Implantable*
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Registries
Risk
Sotalol / therapeutic use*
Tachycardia, Ventricular / mortality,  physiopathology*,  therapy*
Grant Support
ID/Acronym/Agency:
N01-HC-25117/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 3930-20-9/Sotalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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