Document Detail

Stable triazolylphosphonate analogues of phosphohistidine.
MedLine Citation:
PMID:  22105612     Owner:  NLM     Status:  Publisher    
Histidine-phosphorylated proteins and the corresponding kinases are important components of bacterial and eukaryotic cell-signalling pathways, and are therefore potential drug targets. The study of these biomolecules has been hampered by the lability of the phosphoramidate functional group in the phosphohistidines and the lack of generic antibodies. Herein, the design and concise synthesis of stable triazolylphosphonate analogues of N1- and N3-phosphohistidine, and derivatives suitable for bioconjugation, are described.
Shin Mukai; Gavin R Flematti; Lindsay T Byrne; Paul G Besant; Paul V Attwood; Matthew J Piggott
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, 6009, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pilot trial of sunitinib therapy in patients with von Hippel-Lindau disease.
Next Document:  Transglutaminase-mediated modification of ovomucoid: effects on its trypsin inhibitory activity and ...