Document Detail

Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo.
MedLine Citation:
PMID:  20161007     Owner:  NLM     Status:  Publisher    
Understanding lipid metabolism and its regulation requires information on the rates at which lipids are produced within the body, absorbed (dietary lipids) into the body, transported within the body, and utilized by various tissues. This article focuses on the use of stable isotope-labeled tracers for the quantitative evaluation of major pathways of fatty acid and triglyceride metabolism in humans in vivo. Adipose tissue lipolysis and free fatty acid appearance in plasma, fatty acid tissue uptake and oxidation, and hepatic very low-density lipoprotein triglyceride secretion are among the metabolic pathways that can be studied by using stable isotope labeled tracers, and will be discussed in detail. The methodology has been in use for many years and is constantly being refined. A variety of tracers and analytical approaches are available and can be used; knowing the advantages, assumptions, and limitations of each is essential for the planning of studies and the interpretation of data, which can provide unique insights into human lipid metabolism.
Faidon Magkos; Bettina Mittendorfer
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Publication Detail:
Journal Detail:
Title:  Clinical lipidology     Volume:  4     ISSN:  1758-4302     ISO Abbreviation:  -     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101502551     Medline TA:  Clin Lipidol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  215-230     Citation Subset:  -    
Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
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Grant Support
P30 DK056341-08//NIDDK NIH HHS; R01 AR049869-02//NIAMS NIH HHS; R01 AR049869-03//NIAMS NIH HHS; R01 AR049869-04//NIAMS NIH HHS; R01 AR049869-05//NIAMS NIH HHS; M01 RR000036-441502//NCRR NIH HHS; P41 RR000954-27S10255//NCRR NIH HHS; P41 RR000954-31//NCRR NIH HHS; R01 AR049869-01A1//NIAMS NIH HHS; UL1 RR024992-01//NCRR NIH HHS

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