Document Detail


Stable Delineation of the Ischemic Area by the PET Perfusion Tracer 18F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion.
MedLine Citation:
PMID:  21571789     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
(18)F-fluorobenzyl triphenyl phosphonium (FBnTP) has recently been introduced as a myocardial perfusion PET agent. We used a rat model of transient coronary occlusion to determine the stability of the perfusion defect size over time and the magnitude of redistribution. METHODS: Wistar rats (n = 15) underwent thoracotomy and 2-min occlusion of the left coronary artery (LCA), followed by reperfusion. During occlusion, (18)F-FBnTP (92.5 MBq) and (201)Tl-thallium chloride (0.74 MBq) were injected intravenously. One minute before the animals were sacrificed at 5, 45, and 120 min after reperfusion, the LCA was occluded again and 2% Evans blue was injected intravenously to determine the ischemic territory. The hearts were excised, frozen, and sliced for serial dual-tracer autoradiography and histology. Dynamic in vivo (18)F-FBnTP PET was performed on a subgroup of animals (n = 4). RESULTS: (18)F-FBnTP showed stable ischemic defects at all time points after tracer injection and reperfusion. The defects matched the blue dye defect (y = 0.97x+1.5, R(2) = 0.94, y = blue-dye defect, x = (18)F-FBnTP defect). Count density analysis showed no defect fill-in at 45 min but slightly increased activity at 120 min (LCA/remote uptake ratio = 0.19 ± 0.02, 0.19 ± 0.05, and 0.34 ± 0.06 at 5, 45, and 120 min, respectively, P < 0.05). For comparison, (201)Tl showed complete redistribution at 120 min (LCA/remote = 0.42 ± 0.04, 0.72 ± 0.03, and 0.97 ± 0.05 at 5, 45, and 120 min, respectively, P < 0.001). Persistence of the (18)F-FBnTP defect over time was confirmed by in vivo dynamic small-animal PET. CONCLUSION: In a transient coronary occlusion model, perfusion defect size using the new PET agent (18)F-FBnTP remained stable for at least 45 min and matched the histologically defined ischemic area. This lack of significant redistribution suggests a sufficient time window for future clinical protocols with tracer injection remote from the scanner, such as in a stress testing laboratory or chest pain unit.
Authors:
Takahiro Higuchi; Kenji Fukushima; Christoph Rischpler; Takuro Isoda; Mehrbod S Javadi; Hayden Ravert; Daniel P Holt; Robert F Dannals; Igal Madar; Frank M Bengel
Related Documents :
21836089 - Remote ischemic per-conditioning: a novel therapy for acute stroke?
15554029 - The alpha study (t-wave alternans in patients with heart failure): rationale, design an...
22914779 - Target organ crosstalk in the cardiorenal syndrome: animal models.
8582379 - Acute ischaemic lesions in death due to ischaemic heart disease. an autopsy study of 33...
22687629 - Cardiac mechanoenergetics for understanding isoproterenol-induced rat heart failure.
19907159 - The death of john paul jones and resurrection as 'father of the us navy'.
20469439 - Occult cardiac arrhythmias as risk factors for falls in the elderly.
1751179 - Recovery of end-stage organ dysfunction by circulatory assist.
11080949 - Leukocyte-depleted blood cardioplegia reduces cardiac troponin t release in patients un...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-13
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  -     ISSN:  1535-5667     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland; and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of 18F-FDG PET to predict response to first-line tuberculostatics in HIV-associated tuberculosis...
Next Document:  Developmental Changes in P-Glycoprotein Function in the Blood-Brain Barrier of Nonhuman Primates: PE...