Document Detail


Stabilization of telomeres in nonlinear models of proliferating cell lines.
MedLine Citation:
PMID:  17046024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyse an age-structured model of telomere loss in a proliferating cell population. The cell population is divided into telomere classes, which shorten each round of division. The model consists of a nonlinear system of partial differential equations for the telomere classes. We prove that if the highest telomere class is exempted from mortality, then all the classes stabilize to a nontrivial equilibrium dependent on the initial state of cells in the highest telomere class.
Authors:
Janet Dyson; Eva Sánchez; Rosanna Villella-Bressan; Glenn F Webb
Related Documents :
2681364 - Alterations in the responsiveness of senescent cells to growth factors.
2779554 - Reversible cellular senescence: implications for immortalization of normal human diploi...
12488624 - Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics.
9028834 - Generation of a human melanocyte cell line by introduction of hpv16 e6 and e7 genes.
24599174 - Tig3: an important regulator of keratinocyte proliferation and survival.
24060544 - Zinc oxide nanoparticles inhibit ca(2+)-atpase expression in human lens epithelial cell...
Publication Detail:
Type:  Journal Article     Date:  2006-09-16
Journal Detail:
Title:  Journal of theoretical biology     Volume:  244     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  400-8     Citation Subset:  IM    
Affiliation:
Mansfield College, University of Oxford, Oxford, England. janet.dyson@mansfield.ox.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death
Cell Line, Tumor / ultrastructure*
Cell Proliferation
Humans
Logistic Models*
Models, Biological
Nonlinear Dynamics
Telomere / ultrastructure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Are mistakes inevitable? Sex allocation specialization by workers can reduce the genetic information...
Next Document:  Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuropro...