| Stabilization of telomeres in nonlinear models of proliferating cell lines. | |
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MedLine Citation:
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PMID: 17046024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyse an age-structured model of telomere loss in a proliferating cell population. The cell population is divided into telomere classes, which shorten each round of division. The model consists of a nonlinear system of partial differential equations for the telomere classes. We prove that if the highest telomere class is exempted from mortality, then all the classes stabilize to a nontrivial equilibrium dependent on the initial state of cells in the highest telomere class. |
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Authors:
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Janet Dyson; Eva Sánchez; Rosanna Villella-Bressan; Glenn F Webb |
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Publication Detail:
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Type: Journal Article Date: 2006-09-16 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 244 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-08 Completed Date: 2007-03-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 400-8 Citation Subset: IM |
Affiliation:
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Mansfield College, University of Oxford, Oxford, England. janet.dyson@mansfield.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death Cell Line, Tumor / ultrastructure* Cell Proliferation Humans Logistic Models* Models, Biological Nonlinear Dynamics Telomere / ultrastructure* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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