Document Detail


Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer?
MedLine Citation:
PMID:  20589947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physical stability of metastable form I of flufenamic acid (FFA) increased by using mefenamic acid (MFA) as an inclusion compound. We studied the extent of this effect and explained the mechanism by investigating the effect of the presence of MFA on nucleation and crystal growth of the mixed crystals and the effects it has on the surface morphology. We conclude that the polymorphic transformation of FFA was inhibited in the presence of MFA both by lowering the difference in free energy of the MFA/FFA I and MFA/FFA III solid solution crystals, and also by forming an epilayer, thus affecting the kinetics of the polymorphic transformation.
Authors:
Eun Hee Lee; Stephen R Byrn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  99     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4013-22     Citation Subset:  IM    
Affiliation:
Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / chemistry*
Crystallization
Drug Stability
Flufenamic Acid / chemistry*
Mefenamic Acid / chemistry*
Powder Diffraction
Solubility
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 530-78-9/Flufenamic Acid; 61-68-7/Mefenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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