| Stabilization of lysozyme-incorporated polyion complex micelles by the omega-end derivatization of poly(ethylene glycol)-poly(alpha,beta-aspartic acid) block copolymers with hydrophobic groups. | |
| | |
MedLine Citation:
|
PMID: 15779933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To improve the stability of lysozyme-incorporated polyion complex (PIC) micelles in physiological condition, three types of hydrophobic groups, including phenyl (Phe), naphthyl (Nap), and pyrenyl (Py) terminal groups, were separately introduced to the omega-end of poly(ethylene glycol)-poly(alpha,beta-aspartic acid) block copolymers (PEG-P(Asp)). The goal was to enhance association forces between the enzyme, lysozyme, and PEG-P(Asp) carriers. Introduction of these hydrophobic groups significantly decreases micellar critical association concentration and increases the micellar tolerability against increasing NaCl concentrations. Particularly, PIC micelles formed from PEG-P(Asp) with Py groups was most stable against increasing NaCl concentrations up to 0.1 M. Significant deviation from a spherical shape for the micelles was also observed for the PEG-P(Asp)-Py system, consistent with an increased association number. |
| | |
Authors:
|
Xiaofei Yuan; Atsushi Harada; Yuichi Yamasaki; Kazunori Kataoka |
Related Documents
:
|
12139263 - Dental erosion patterns from intrinsic acid regurgitation and vomiting. 18181093 - Synthesis and characterization of functionalized biodegradable poly(dl-lactide-co-rs-be... 718973 - Synthesis of trinitrophenylaminolauric acid and the use of its glyceryl esters for assa... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Langmuir : the ACS journal of surfaces and colloids Volume: 21 ISSN: 0743-7463 ISO Abbreviation: Langmuir Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-03-22 Completed Date: 2006-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
|
Languages: eng Pagination: 2668-74 Citation Subset: IM |
Affiliation:
|
Department of Materials Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aspartic Acid
/
analogs & derivatives*,
chemistry* Hydrophobicity Ions / chemistry Micelles* Muramidase / metabolism* Polyethylene Glycols / chemistry* Polymers / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Ions; 0/Micelles; 0/Polyethylene Glycols; 0/Polymers; 56-84-8/Aspartic Acid; EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fabrication of superhydrophobic surfaces from microstructured ZnO-based surfaces via a wet-chemical ...
Next Document: Dediazoniation in SDS/BuOH/H2O reverse micelles: structural parameters, kinetics, and mechanism of t...